• 专利附录
  • 专利说明
  • 权利要求
  • 类似技术
  • 同族专利
  • 引用文献
  • 法律状态
  • 优先权
    • 专利摘要:
    A method of manufacturing a contact lens A method of manufacturing a contact lens involves depositing on a portion of a molding surface of a contact lens mold a dye composition comprising a pigment, a 2-hydroxyethyl methacrylate copolymer and a vinylpyrrolidinone, and a cross-linking monomer.
    公开号:BR112012001542B1
    申请号:R112012001542
    申请日:2010-07-20
    公开日:2019-08-13
    发明作者:Chapoy Lawrence；Fanqing Meng Richard；Mao Shane
    申请人:Bausch & Lomb；
    IPC主号:
    专利说明:

    FIELD [0002] This invention provides a contact lens comprising a hydrophilic copolymer substrate and a composition containing colorant on a surface of the substrate. The dye-containing composition comprises a pigment, a copolymer of 2-hydroxyethyl methacrylate and N-vinylpyrrolidinone, and a crosslinking monomer.
    BACKGROUND OF THE INVENTION [0003] A representative crosslinking monomer is ethylene glycol dimethacrylate or 1,4-butanediol diacrylate. A representative pigment is iron oxide black or iron oxide brown.
    [0004] The dye-containing composition may include other components. A first example is a hydrophilic co-monomer, such as 2-hydroxyethyl methacrylate. A second example is a hydrophobic comonomer, such as 2-butoxyethyl acrylate. A third example is ethyl lactate. In addition, these compositions will generally include a polymerization initiator.
    [0005] The contact lens substrate can be made from any known hydrophilic copolymer. A preferred copolymer is hilafilcon B, which is the product of the polymerization of a monomer mixture comprising 2-hydroxyethyl methacrylate, N-vinylpyrrolidinone, ethylene glycol dimethacrylate, and allyl methacrylate.
    [0006] Preferably, the dye-containing composition has a concentric ring shape on the surface. Most preferably, the concentric ring essentially conforms to a position of a human iris when the contact lens is placed on the eye, and can have a larger outside diameter than a human iris.
    SUMMARY OF THE INVENTION
    Petition 870190053694, of 12/06/2019, p. 6/31
    2/8 [0007] The invention provides a method of making the contact lens comprising:
    depositing on a portion of a molding surface of a contact lens mold a dye composition comprising a pigment, a copolymer of 2-hydroxyethyl methacrylate and N-vinylpyrrolidinone, and a crosslinking monomer, and at least partially curing the composition dye by exposure to thermal or luminous energy; and depositing a lens-forming monomer mixture into the mold, and curing the lens-forming monomer mixture, where the colorant composition is on a cured contact lens surface.
    [0008] Preferably, the contact lens mold is made of a polyolefin, most preferably polypropylene. The dye composition is deposited on a portion of the molding surface of the contact lens, preferably an anterior mold of the contact lens. The dye composition can be applied with a pad. For example, the dye composition is applied first to the wick of a cliché having the desired dye pattern, and then the dye composition is transferred from the wad to the molding surface of the contact lens.
    [0009] As previously mentioned, the dye composition is preferably applied to form a concentric ring shape that essentially conforms to a position of a human iris when the contact lens is placed on the eye.
    [0010] The colorant composition is at least partially cured, before depositing the lens-forming monomer mixture in the mold. A preferred method of curing is by exposing the dye composition to light energy, more preferably UV light.
    [0011] After curing the lens-forming monomer mixture, the contact lens is released from the mold, preferably by a dry release method.
    [0012] It is important that the colorant composition has several physical properties that approximate those of the hydrophilic copolymer substrate of the lens.
    Petition 870190053694, of 12/06/2019, p. 7/31
    3/8 contact. These properties include expansion coefficient and water content. Otherwise, the cured colorant composition may not bond properly with the contact lens substrate. This is especially important for processes where the contact lens is released dry from the mold so that both the dye composition and the contact lens substrate copolymer do not have a significantly different adhesion than the mold material.
    [0013] However, it is also important that the dye composition is printable on the surface of the mold. Polypropylene is relatively hydrophobic, and when employing a hydrophilic dye composition, the composition has a tendency to turn the edges. An earlier approach to this problem involved subjecting the molding surface of the contact lens to a high energy source, such as corona discharge. However, it is difficult to control such treatments, and such treatments require longer production times and higher production costs. For the present invention, it is preferred that the contact lens mold is not subjected to any such high energy treatment. In contrast, the dye composition may employ a water-miscible solvent so that the surface tension of the dye composition better matches that of the mold material. Also, by using dye compositions with sufficiently high viscosity (at least 2000 cp), the higher surface tension of the composition can be deflected to prevent the edges from rolling upwards on the mold surface.
    DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS [0014] The following examples illustrate various embodiments of the present invention.
    EXAMPLE 1 - POLY SYNTHESIS (HEMA-CO-NVP) [0015] To a 2 L round bottom flask and three necks equipped with mechanical stirring, condenser and nitrogen inlet were added 2-hydroxyethyl methacrylate (HEMA) ( 344.4g, 2.65 moles), N-vinylpyrrolidone (NVP) (165g, 1.48 moles), 2-mercaptoethanol (4.68g, 0.06 moles) and cyclopentanone (684g, 720ml). The above mixture was purged by bubbling N2 for 15 minutes
    Petition 870190053694, of 12/06/2019, p. 8/31
    4/8 before the Vazo 64 initiator was added. The reaction was heated to 38 ° C for 48 hours, then to 70 ° C overnight. This solution was diluted with 1200 ml of isopropanol (EPA). The resulting solution was added to 6 L of diethyl ether in drops slowly from an addition funnel under vigorous stirring of the mechanical stirrer. 500 g of white powder were collected after being filtered and dried in the oven at 70 ° C under vacuum (30 mmHg) overnight.
    [0016] The reaction is illustrated below.
    EXAMPLE 2 - INK CONTAINING POLY COPOLYMER (HEMA-CO-NVP). FORMATION OF THE PASTE CONTAINING IRON OXIDE BLACK [0017] 210 g of zirconium oxide ceramic medium, 210 g of iron oxide black and 210 g of ethyl lactate were added to a 500 ml ceramic bottle, and mixed thoroughly with an ink shaker for 200 minutes. The paste had a particle size of 5pm. This paste with the ceramic media was added to a sieve installed in a bottle, and the bottle was then sealed with its cap and another counter-bottle. The whole was centrifuged, and the entire paste was deposited at the bottom of the bottle through the sieve and all the ceramic granules remained in the sieve. The particle size of the iron oxide black was 5pm.
    FORMATION OF THE BINDING SOLUTION [0018] 53, 27g of poly (HEMA-co-NVP) (Wm = 20, 810) and 35.51 g of (-) ethyl lactate were added to a 500 ml plastic cup, mixed thoroughly for 10 minutes, and allowed to settle overnight after mixing. 88.97 g of binder solution containing 60% copolymer were obtained.
    ACTIVATION SOLUTION FORMATION [0019] 14.00 g HEMA were added to a 30 ml brown glass vial with a magnetic bar, then 3 g of EGDMA and 3 g of Lucirin TPO initiator
    Petition 870190053694, of 12/06/2019, p. 9/31
    5/8 were added in sequence. The mixture was stirred until the solid initiator was dissolved (about 10 minutes). 20 g of activation solution were obtained.
    INK COMPOSITION FORMATION [0020] 88.79g of paste containing iron oxide black, 88.79g of binder solution and 19.73g of activation solution were added sequentially to a 500 ml plastic cup, mixed for 10 minutes to obtain 197.30 g of paint composition containing the following components.
    Table 1
    Component % by weight Iron oxide black 22.5 Poli (HEMA-co-NVP) 27 (-) ethyl lactate 40.5 HEMA 7 EGDMA 1.50 Lucirin TPO Initiator 1.50 Total 100.00
    [0021] The ink composition had the following viscosity profile, as measured with a Brookfield digital viscometer, model DV-II +, spindle: SPE-51; Temperature: 25.4 ° C.
    Speed (cP) % Torque Viscosity 0.5 4.9 5074 1 7 3625 2 9.4 2434 2.5 11.4 2361 4 14.7 1903 5 16.6 1719
    COMPARATIVE EXAMPLE 3 - POLY INK COMPOSITION (HEMA) [0022] An ink composition is prepared from the following components.
    Table 2
    Petition 870190053694, of 12/06/2019, p. 10/31
    6/8
    Component % by weight Iron oxide black 22.00 Poli-HEMA 27.60 Ethyl lactate 22.00 Cyclopentanone 18.40 HEMA 9.00 EGDMA 0.50 Lucirin TPO Initiator 0.50 Total 100.00
    BINDING SOLUTION FORMATION [0023] 41.40 g poly-HEMA (Wm = 20,000) and 27.60 g cyclopentanone were added to a 500 ml plastic cup, mixed thoroughly for 10 minutes, and allowed to settle during night after mixing. 67.57 g of 60% poly-HEMA binder solution was obtained.
    ACTIVATION SOLUTION [0024] 13,500 g HEMA were added to a brown ml glass vial with a magnetic stir bar, and 0.73 g EGDMA and 0.73 g Lucirin TPO initiator were added sequentially. The mixture was stirred until the solid initiator was dissolved (about 10 minutes). 15.00 g of activation solution were obtained.
    INK COMPOSITION [0025] 64.63g of paste containing iron oxide black of example 2a, 67.57 g of poly-HEMA binder solution and 14.69 g of activation solution were added sequentially to a plastic cup of 500 ml, and mixed for 10 minutes. The paint composition had the following viscosity profile, as measured with a Brookfield digital viscometer, model DV-II +, spindle: SPE-51; Temperature: 25.4 ° C.
    Speed (cP)% Torque
    Viscosity
    Petition 870190053694, of 12/06/2019, p. 11/31
    7/8
    0.5 4.5 4660 1 7.3 3780 2 10.1 2615 2.5 12.2 2527 4 15.2 1968 5 17.1 1771
    EXAMPLE 4 - INK CONTAINING POLY COPOLYMER (HEMA-CO-NVP)
    Table 3
    Final ink formulation % in real weight Iron oxide brown 20 Poli (HEMA-co-NVP) 30 ethyl lactate 40 2-butoxyethyl acrylate 7 1,4-butanediol diacrylate 1.50 Lucirin TPO initiator 1.50 Total 100.00
    The. Following the general procedure of example 2a, but replacing the brown iron oxide pigment, a pigment paste is obtained.
    B. Following the general procedure of Example 2b, poly (HEMA-co-NVP) and ethyl lactate are combined to form a binder solution, and it was added to a 500 ml plastic cup, mixed thoroughly for 10 minutes, and allowed to settle overnight after mixing. 88, 97g of the binder solution containing 60% copolymer were obtained.
    ç. Following the general procedure of example 2c, 2-butoxyethyl acrylate, 1,4-butanediol diacrylate, and Lucirin TPO initiator are combined to form an activation solution.
    d. Following the general procedure of example 2d, the pigment containing iron oxide brown, the binder solution and the activation solution are combined to form an ink composition.
    [0026] The illustrated examples and embodiments demonstrate some
    Petition 870190053694, of 12/06/2019, p. 12/31
    8/8 of the sustained release embodiments of the present invention. However, it should be understood that these examples are for illustrative purposes only and are not intended to be completely definitive with respect to conditions and scope. When the invention is described in connection with the various preferred embodiments, numerous variants will be apparent to one skilled in the art given the present description, without departing from the spirit of the invention and the scope of the appended claims.
    权利要求:
    Claims (8)
    [1]
    1. Method for making a contact lens, characterized by the fact that it comprises:
    depositing on a portion of a molding surface of a contact lens mold a coloring composition comprising a pigment, a copolymer of 2-hydroxyethyl methacrylate and N-vinylpyrrolidinone, and a crosslinking monomer, the coloring composition having a Brookfield viscosity at least 2000 cp and the contact lens mold is made of polyolefin;
    at least partially curing the colorant composition;
    depositing a lens-forming monomer mixture in the mold, and curing the lens-forming monomer mixture, where the colorant composition is on a cured contact lens surface.
    [2]
    2. Method according to claim 1, characterized by the fact that the contact lens mold is made of polypropylene.
    [3]
    Method according to claim 1, characterized in that the colorant composition is deposited on a portion of the molding surface of an anterior contact lens mold.
    [4]
    Method according to claim 1, characterized in that the lens-forming monomer mixture comprises hydroxyethyl methacrylate, N-vinylpyrrolidinone, and a cross-linking monomer.
    [5]
    Method according to claim 1, characterized in that the dye composition is deposited to form a concentric ring shape.
    [6]
    6. Method according to claim 5, characterized in that the concentric ring essentially conforms to a position of a human iris when the contact lens is placed on the eye.
    [7]
    7. Method according to claim 6, characterized by the fact that the concentric ring has an outside diameter larger than a human iris.
    [8]
    8. Method according to claim 1, characterized by the fact that
    Petition 870190053694, of 12/06/2019, p. 14/31
    2/2 further understand, after curing the lens-forming monomer mixture, dryly release the contact lens from the mold.
    类似技术:
    公开号 | 公开日 | 专利标题
    BR112012001542B1|2019-08-13|method for manufacturing a contact lens
    FI93906C|1995-06-12|Hydrophilic color contact lenses
    DE69828351T2|2005-12-08|Polymer molded article having a hydrophilic surface and process for its preparation
    US3607848A|1971-09-21|Method for preparing insoluble,cross-linked organic hydrogels comprising copolymers of glycol monoesters with diesters
    US20040056371A1|2004-03-25|Method of manufacturing ophthalmic lenses made from hydrophobic acrylic polymers
    PT2038310E|2010-08-25|Actinically crosslinkable copolymers for manufacturing contact lenses
    TW201004789A|2010-02-01|Tinted silicone ophthalmic devices, processes and polymers used in the preparation of the same
    AU2008366094A1|2013-02-07|Cosmetic contact lenses having a sparkle effect
    BR0014987B1|2011-08-09|method of producing a silicone hydrogel and silicone hydrogel lens.
    CA2944216A1|2015-10-08|Silicone acrylamide copolymer
    EP3126416A1|2017-02-08|Silicone acrylamide copolymer
    TW201716515A|2017-05-16|Coloring material, coloring film, method for making the coloring film, and eye lens
    JP2014196500A|2014-10-16|Improved method of producing tinted polymers
    TWI518128B|2016-01-21|Polymerizable composition for coloring contact lens
    ES2887736T3|2021-12-27|Composition of silicone hydrogel, silicone hydrogel lens and manufacturing method of silicone hydrogel lens
    CN110655604A|2020-01-07|Physical hydrogel and preparation method thereof
    JP2005146227A|2005-06-09|Antifogging coating, antifogging formed article and method for producing antifogging coating
    TWI521020B|2016-02-11|Mesh polymer, used in the production of medical equipment and medical equipment
    JP5764925B2|2015-08-19|Method for producing silicone prepolymer
    TW201714977A|2017-05-01|Coloring material, coloring film, method for making the coloring film, and eye lens
    TWI698453B|2020-07-11|Anti-blue light material and preparation method thereof
    CA1296840C|1992-03-10|Prosthesis of female mamma and the method of producing thereof
    CN104924508B|2017-04-05|For the manufacture method of the mould of contact lenses, method for sorting and contact lenses
    TW202000712A|2020-01-01|Device for anti-blue-light and manufacturing method thereof
    AU2015200687B2|2016-04-21|Cosmetic contact lenses having a sparkle effect
    同族专利:
    公开号 | 公开日
    WO2011011344A1|2011-01-27|
    BR112012001542A2|2016-04-19|
    EP2457122A1|2012-05-30|
    US20110063568A1|2011-03-17|
    CN102597853B|2014-06-18|
    US8461226B2|2013-06-11|
    KR20180017219A|2018-02-20|
    CA2767058C|2015-02-17|
    JP5739423B2|2015-06-24|
    KR101912572B1|2018-10-26|
    CN102597853A|2012-07-18|
    IN2012DN00299A|2015-05-08|
    SG177509A1|2012-02-28|
    CA2767058A1|2011-01-27|
    KR20120041736A|2012-05-02|
    JP2013500499A|2013-01-07|
    引用文献:
    公开号 | 申请日 | 公开日 | 申请人 | 专利标题
    US4701288A|1985-06-05|1987-10-20|Bausch & Lomb Incorporated|Method of making articles of dissimilar polymer compositions|
    US4719657A|1986-03-27|1988-01-19|Bausch & Lomb Incorporated|Method of forming iris variegation patterns on contact lenses|
    US5120121A|1988-07-21|1992-06-09|Allergan, Inc.|Colored lens|
    US5034166A|1988-07-21|1991-07-23|Allergan, Inc.|Method of molding a colored contact lens|
    AR247580A1|1989-01-30|1995-01-31|Pfortner Cornealent S A C I F|Procedure for preparing coloured lacquers and varnishes for colouring contact lenses or transparent ones, the transparent or pigmented lacquers that are obtained this way and the contact lenses coloured with these|
    EP0472496A3|1990-08-20|1992-12-02|Ciba-Geigy Ag|Method of producing a contact lens and contact lens produced thereby|
    JPH06123862A|1992-10-09|1994-05-06|Tokyo Keikaku:Kk|Soft contact lens|
    JPH06258605A|1993-03-05|1994-09-16|Seed:Kk|Colored contact lens and its production|
    JP4411358B2|1998-02-26|2010-02-10|株式会社ワールドマンセル|Manufacturing method of color vision correction contact lens|
    FR2789081B1|1999-01-28|2001-04-20|Essilor Int|METHOD FOR COLORING FLEXIBLE HYDROPHILIC CONTACT LENSES|
    US7048375B2|1999-11-01|2006-05-23|Praful Doshi|Tinted lenses and methods of manufacture|
    AR029115A1|2000-06-12|2003-06-04|Novartis Ag|COLORS FOR PRINTING BY INK JETS, ON CONTACT LENSES|
    US6811259B2|2000-06-12|2004-11-02|Novartis Ag|Printing colored contact lenses|
    US20020196409A1|2001-06-22|2002-12-26|Bausch & Lomb Incorporated|Lens with colored portion|
    US20030117576A1|2001-12-05|2003-06-26|Ocular Sciences, Inc.|Colored contact lenses|
    JP2004021244A|2002-06-13|2004-01-22|Hisayo Ebiko|Color contact lens and its serving method|
    US6852254B2|2002-06-26|2005-02-08|Johnson & Johnson Vision Care, Inc.|Methods for the production of tinted contact lenses|
    US7021761B2|2002-06-28|2006-04-04|Bausch & Lomb Incorporated|Lens with colored portion and coated surface|
    US8147728B2|2004-04-01|2012-04-03|Novartis Ag|Pad transfer printing of silicone hydrogel lenses using colored ink|
    DE602005016262D1|2004-07-28|2009-10-08|Novartis Ag|WATER-BASED INK FOR HYDROGELLINS|
    CN2864730Y|2005-10-21|2007-01-31|周振宇|Stealth sunglass|
    US20070296917A1|2006-06-23|2007-12-27|Bowers Jackie W|Tinted contact lenses having iris patterns with enhanced depth|
    US20080128930A1|2006-12-01|2008-06-05|Yu-Chin Lai|Method of Releasing Contact Lens|
    CA2671740C|2006-12-13|2015-08-11|Novartis Ag|Actinically curable silicone hydrogel copolymers and uses thereof|
    US20090108479A1|2007-10-26|2009-04-30|Bausch & Lomb Incorporated|Method for Making Biomedical Devices|US8798332B2|2012-05-15|2014-08-05|Google Inc.|Contact lenses|
    US8857981B2|2012-07-26|2014-10-14|Google Inc.|Facilitation of contact lenses with capacitive sensors|
    US9523865B2|2012-07-26|2016-12-20|Verily Life Sciences Llc|Contact lenses with hybrid power sources|
    US9298020B1|2012-07-26|2016-03-29|Verily Life Sciences Llc|Input system|
    US9158133B1|2012-07-26|2015-10-13|Google Inc.|Contact lens employing optical signals for power and/or communication|
    US8919953B1|2012-08-02|2014-12-30|Google Inc.|Actuatable contact lenses|
    US9696564B1|2012-08-21|2017-07-04|Verily Life Sciences Llc|Contact lens with metal portion and polymer layer having indentations|
    US9111473B1|2012-08-24|2015-08-18|Google Inc.|Input system|
    US8820934B1|2012-09-05|2014-09-02|Google Inc.|Passive surface acoustic wave communication|
    US20140192315A1|2012-09-07|2014-07-10|Google Inc.|In-situ tear sample collection and testing using a contact lens|
    US9398868B1|2012-09-11|2016-07-26|Verily Life Sciences Llc|Cancellation of a baseline current signal via current subtraction within a linear relaxation oscillator-based current-to-frequency converter circuit|
    US10010270B2|2012-09-17|2018-07-03|Verily Life Sciences Llc|Sensing system|
    US9326710B1|2012-09-20|2016-05-03|Verily Life Sciences Llc|Contact lenses having sensors with adjustable sensitivity|
    US8870370B1|2012-09-24|2014-10-28|Google Inc.|Contact lens that facilitates antenna communication via sensor impedance modulation|
    US8960898B1|2012-09-24|2015-02-24|Google Inc.|Contact lens that restricts incoming light to the eye|
    US20140088372A1|2012-09-25|2014-03-27|Google Inc.|Information processing method|
    US8979271B2|2012-09-25|2015-03-17|Google Inc.|Facilitation of temperature compensation for contact lens sensors and temperature sensing|
    US8989834B2|2012-09-25|2015-03-24|Google Inc.|Wearable device|
    US8960899B2|2012-09-26|2015-02-24|Google Inc.|Assembling thin silicon chips on a contact lens|
    US8821811B2|2012-09-26|2014-09-02|Google Inc.|In-vitro contact lens testing|
    US9884180B1|2012-09-26|2018-02-06|Verily Life Sciences Llc|Power transducer for a retinal implant using a contact lens|
    US8985763B1|2012-09-26|2015-03-24|Google Inc.|Contact lens having an uneven embedded substrate and method of manufacture|
    US9063351B1|2012-09-28|2015-06-23|Google Inc.|Input detection system|
    US8965478B2|2012-10-12|2015-02-24|Google Inc.|Microelectrodes in an ophthalmic electrochemical sensor|
    US9176332B1|2012-10-24|2015-11-03|Google Inc.|Contact lens and method of manufacture to improve sensor sensitivity|
    US9757056B1|2012-10-26|2017-09-12|Verily Life Sciences Llc|Over-molding of sensor apparatus in eye-mountable device|
    US8874182B2|2013-01-15|2014-10-28|Google Inc.|Encapsulated electronics|
    US9289954B2|2013-01-17|2016-03-22|Verily Life Sciences Llc|Method of ring-shaped structure placement in an eye-mountable device|
    US20140209481A1|2013-01-25|2014-07-31|Google Inc.|Standby Biasing Of Electrochemical Sensor To Reduce Sensor Stabilization Time During Measurement|
    US9636016B1|2013-01-25|2017-05-02|Verily Life Sciences Llc|Eye-mountable devices and methods for accurately placing a flexible ring containing electronics in eye-mountable devices|
    US9161712B2|2013-03-26|2015-10-20|Google Inc.|Systems and methods for encapsulating electronics in a mountable device|
    US9113829B2|2013-03-27|2015-08-25|Google Inc.|Systems and methods for encapsulating electronics in a mountable device|
    US20140371560A1|2013-06-14|2014-12-18|Google Inc.|Body-Mountable Devices and Methods for Embedding a Structure in a Body-Mountable Device|
    US9084561B2|2013-06-17|2015-07-21|Google Inc.|Symmetrically arranged sensor electrodes in an ophthalmic electrochemical sensor|
    US9948895B1|2013-06-18|2018-04-17|Verily Life Sciences Llc|Fully integrated pinhole camera for eye-mountable imaging system|
    US9685689B1|2013-06-27|2017-06-20|Verily Life Sciences Llc|Fabrication methods for bio-compatible devices|
    US9028772B2|2013-06-28|2015-05-12|Google Inc.|Methods for forming a channel through a polymer layer using one or more photoresist layers|
    US9814387B2|2013-06-28|2017-11-14|Verily Life Sciences, LLC|Device identification|
    US9307901B1|2013-06-28|2016-04-12|Verily Life Sciences Llc|Methods for leaving a channel in a polymer layer using a cross-linked polymer plug|
    US9492118B1|2013-06-28|2016-11-15|Life Sciences Llc|Pre-treatment process for electrochemical amperometric sensor|
    US9572522B2|2013-12-20|2017-02-21|Verily Life Sciences Llc|Tear fluid conductivity sensor|
    US9654674B1|2013-12-20|2017-05-16|Verily Life Sciences Llc|Image sensor with a plurality of light channels|
    US9366570B1|2014-03-10|2016-06-14|Verily Life Sciences Llc|Photodiode operable in photoconductive mode and photovoltaic mode|
    US9184698B1|2014-03-11|2015-11-10|Google Inc.|Reference frequency from ambient light signal|
    US9789655B1|2014-03-14|2017-10-17|Verily Life Sciences Llc|Methods for mold release of body-mountable devices including microelectronics|
    KR101626201B1|2014-05-30|2016-06-01|조선대학교산학협력단|Ink composition for cosmetic color contact lens|
    KR101949146B1|2017-10-24|2019-02-18|주식회사 인터로조|A Contact Lens Having A Blue-based Identification Color and Manufacturing Method Thereof|
    KR102145423B1|2018-12-06|2020-08-18|순천향대학교 산학협력단|Method for manufacturing contact lenses using ink-jet|
    CN110256900A|2019-06-28|2019-09-20|甘肃天后光学科技有限公司|A kind of intermediate and preparation method thereof for colored ink|
    法律状态:
    2019-01-15| B06F| Objections, documents and/or translations needed after an examination request according art. 34 industrial property law|
    2019-04-16| B06T| Formal requirements before examination|
    2019-07-23| B09A| Decision: intention to grant|
    2019-08-13| B16A| Patent or certificate of addition of invention granted|Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 20/07/2010, OBSERVADAS AS CONDICOES LEGAIS. (CO) 20 (VINTE) ANOS CONTADOS A PARTIR DE 20/07/2010, OBSERVADAS AS CONDICOES LEGAIS |
    优先权:
    申请号 | 申请日 | 专利标题
    US22822009P| true| 2009-07-24|2009-07-24|
    PCT/US2010/042499|WO2011011344A1|2009-07-24|2010-07-20|Contact lens|
    [返回顶部]